Onéox : Development of new bioactive compounds PDF Print E-mail

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Medicinal Chemistry of Polyphenols : their potential use as bioactive compounds

Introduction :

A team from the Department of Medicinal Chemistry is expert in the extraction of natural active substances as well as in the development and synthesis of analogues. These new synthesized compounds can prove to be highly advantageous to companies interested in identifying new molecules of therapeutic and cosmetic value.

The department has patented a number of inventions related to the use of  polyphenol derivatives in pharmacy and cosmetology which in turn have led to the commercialization of active polyphenols in cosmetology. These factors may differentiate the department from other laboratories and can potentially lead to reduced lead times necessary for synthesizing or extracting new molecules.

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Therapeutic Molecules

Two principal services are available from the department, namely the extraction of molecules from natural sources as well as the synthesis of natural products and their analogs.

Natural Molecules: overview of services on offer

  • Preparation of extracts from natural sources

New synthesised organic molecules : overview of services on offer

  • Synthesis of natural polyphenols derivatives and especially flavonoids 
    • Short synthesis methods
    • Scale-up (in terms of quantities produced)
  • Characterization
    • Structural analysis
    • Stability studies
    • Toxicity profile
  • Optimization of bioactive derivatives
    • Pharmaco-modulation
    • Structure - activity relationships
Consulting activity
  • Evaluation of project viability
  • Proposals relating to innovative projects

pommes.jpgKey Benefits

The following are examples of the types of new molecules that are either already available or can be extracted/synthesised through research programmes

  • New source of antioxydants
  • Prevention of cardio-vascular illnesses
  • Anticancer agents targeting the mitotic spindle
  • Inhibitors for proteins causing multiple resistance to chemotherapy treatment
  • Inhibitors and activators of CFTR channels
  • Anti-inflammatoires
  • Antibacterials
  • Anti-parasite molecules
  • Antivirals

Fields of use

Pharmaceutical industries (oncology, parasitology, inflammation, cardiovascular illnesses, ederly)

Cosmetics

Drug Development

Agribusiness (food manufacturing and nutraceutical products)

Contacts
Véronique Sendra
+33 (0)4 76 00 78 30
This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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TECHNOLOGY FOCUS

TESTIMONIALS

« When we identified Professor Drouet's technology at the UJF it was immediately apparent that this invention met all our needs." T Paper - Biosynex
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