Elemental selenium, an essential micronutrient to combat oxidative stress

Introduction

Although toxic in large amounts, selenium is a key trace element that plays an important role in the functioning of antioxidant enzymes involved in the removal of free reactive oxygen species responsible for the cell damages related to oxidative stress. A team of researchers at the University of Grenoble has recently developed a novel synthesis pathway giving access to stable composite nanoparticles made of calcite and elemental selenium, allowing biological delivery to the human body of a form of selenium⁰.

Selenium nanoparticles were recently reported to have:
- less negative effects (toxicity) when compared to elemental selenium
- enhanced biological activities with regards to oxidative stress and cancer

Nanoparticles such as this that contain selenium could prove to be highly relevant for food supplement type applications.

Key Features and innovative aspects

• An original synthesis pathway using the amino acid seleno-L-cystine and calcium hydroxide (Ca(OH)2) to produce stable calcite- selenium nanoparticles
• Enhanced bioavailability
• Reduced toxicity towards human cells

Main Applications

The main application of these novel elemental selenium containing nano-particles concerns the area of nutrition and dietary supplements related to anti oxidative stress.

Intellectual Property

The Selenium containing nanoparticles, their synthesis pathway and their use as dietary supplements are protected by European patent # 08 290 234.7

Commercial Opportunity
We are currently searching for industrial partners interested in licensing or co-developing this technology.

Contact
Mathieu Tilquin
+33 (0)4 76 00 78 41
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