Elemental selenium, an essential micronutrient to combat oxidative stress
Introduction
Although toxic in large amounts, selenium is a key trace element that plays an important role in the functioning of antioxidant enzymes involved in the removal of free reactive oxygen species responsible for the cell damages related to oxidative stress. A team of researchers at the University of Grenoble has recently developed a novel synthesis pathway giving access to stable composite nanoparticles made of calcite and elemental selenium, allowing biological delivery to the human body of a form of selenium0.
Medicinal Chemistry of Polyphenols : their potential use as bioactive compounds
Introduction :
A team from the Department of Medicinal Chemistry is expert in the extraction of natural active substances as well as in the development and synthesis of analogues. These new synthesized compounds can prove to be highly advantageous to companies interested in identifying new molecules of therapeutic and cosmetic value.
The department has patented a number of inventions related to the use of polyphenol derivatives in pharmacy and cosmetology which in turn have led to the commercialization of active polyphenols in cosmetology. These factors may differentiate the department from other laboratories and can potentially lead to reduced lead times necessary for synthesizing or extracting new molecules.
Sugar-Derivated Polyhydroxylated Nitrones as Novel Water-Soluble Radical Traps
This technology is an original and highly efficient process outlining the preparation of two novel classes of compounds exhibiting anti-oxidative properties (European Patent n°2007 00973). We are currently seeking industrial partners interested in carrying out in-vivo tests to demonstrate the potential of these new molecules in combating oxidative stress.
Although toxic in large amounts, selenium is a key trace element that plays an important role in the functioning of antioxidant enzymes involved in the removal of free reactive oxygen species responsible for the cell damages related to oxidative stress. A team of researchers at the University of Grenoble has recently developed a novel synthesis pathway giving access to stable composite nanoparticles made of calcite and elemental selenium, allowing biological delivery to the human body of a form of selenium0.